The manuscript collections in the Research Center include individual and family papers and institutional records, representing a broad range of activities and interests. The museum holds over 500 manuscript collections, ranging in size from a few items to over 150 linear feet. A diverse array of documents, such as letters, diaries, legal and financial documents and printed material can be found in the collections, providing a first-hand record of life on the plains.
The collections are particularly deep in material related to ranching, petroleum exploration and development, politics, architecture, and art and artists. The Research Center serves as a repository for non-current records of many Texas Panhandle local governments.
Finding aids are available in the museum for many collections. A card index provides additional access for other collections.